Interplay between adenylate metabolizing enzymes and AMP‐activated protein kinase
نویسندگان
چکیده
منابع مشابه
Functional protein-protein interaction of drug metabolizing enzymes.
Cytochrome P450 (P450, CYP), a major class of enzymes involved in Phase I drug metabolism, is expressed in the cellular endoplasmic reticulum together with other enzymes, such as microsomal epoxide hydrolase (mEH) and UDP-glucuronosyltransferase (UGT). In many cases, the metabolite produced by P450 is sequentially metabolized by other enzymes to increase its water solubility. It would be reason...
متن کاملRelationship between protein kinase C and derepression of different enzymes.
The PKC1 gene in the yeast Saccharomyces cerevisiae encodes for protein kinase C which is known to control a MAP kinase cascade consisting of different kinases: Bck1, Mkk1 and Mkk2, and Mpk1. This cascade affects the cell wall integrity but the phenotype of pkc1Delta mutants suggests additional targets that have not yet been identified [Heinisch et al., Mol. Microbiol. 32 (1999) 671-680]. The p...
متن کاملDialogue between membranes and their lipid-metabolizing enzymes.
Biological chemists have often regarded the fluidity or plasticity of a membrane as a property that may be adaptively altered to accommodate changes in environmental temperature. The implication that cells exhibit an intelligent (or at least, appropriate) response provides us with several questions to examine. (1) Is temperature or some aspect of fluidity perceived by the responsive cellular el...
متن کاملInterplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier.
The recent identification of drug-metabolizing enzymes cytochrome P450 (CYP) in the human blood-brain barrier (BBB) raises the question of whether these enzymes act in concert with ATP-binding cassette (ABC) transporters to limit the brain distributions of drugs. We recently demonstrated several CYP genes in freshly isolated human brain microvessels; the main isoforms expressed were CYP1B1 and ...
متن کاملProtein kinase C sensitizes olfactory adenylate cyclase
Effects of neurotransmitters on cAMP-mediated signal transduction in frog olfactory receptor cells (ORCs) were studied using in situ spike recordings and radioimmunoassays. Carbachol, applied to the mucosal side of olfactory epithelium, amplified the electrical response of ORCs to cAMP-generating odorants, but did not affect unstimulated cells. A similar augmentation of odorant response was obs...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2018
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.14508